ON NECROSIS.

Observations on Necrosis

'E now know, that, in the long bones of the human body, a portion of the bony cylinder may be deprived of the living principle; and that, in fuch cafes, nature gradually feparates the living from the dead part. While this feparation is taking place, a new cylinder is formed by an effufion of bony matter, fo as to inclofe the old bone, as it were, in a cafe ; and the new bone conneding itfelf wi...

Digital Necrosis: A Hoarder’s Tale

Cutaneous necrosis following brown recluse spider bite

Tumor necrosis factor: receptors on hematopoietic cells.

Tumor necrosis factor (TNF) is a monokine that is cytotoxic/cytostatic for a variety of tumor cells and has multiple effects on normal cells. We demonstrate that normal and malignant human myeloid cells express a single class of high-affinity receptors (400 to 1,900 per cell, KD 20 to 90 pmol/L) for TNF. Mitogen-stimulated lymphocytes have a similar number of TNF receptors, whereas resting lymp...

Renal papillary necrosis--40 years on.

Analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized as a major class of therapeutic agent that causes renal papillary necrosis (RPN). Over the last decade a broad spectrum of other therapeutic agents and many chemicals have also been reported that have the potential to cause this lesion in animals and man. There is consensus that RPN is the primary lesion that can p...